PHARMACOLOGY

Rather mysteriously, ModafinilCat closed up shop on September 28, 2016. They cite the fact that ModafinilCat was a time sink that detracted from their other ventures. As of this morning, ModafinilCat now redirects visitors to AfinilExpress.

Adrafinil Half-Life

October 31, 2016

A study conducted in rats found that the half-life of adrafinil is about 4.95 hours[^1] However, in humans, the biological half-life is about 1 hour.

Unlike benzodiazepines, z-drugs, and other habit-forming sleep aids, Suvorexant and Ramelteon bind to the receptors for melatonin and orexin. (Melatonin is a a sleep-promoting neurohormone produced by the pineal gland and orexin is a wake-promoting neuropeptide.) Insomniacs and sufferers of delayed sleep phase disorder will be pleased to learn that their sleep conditions can be managed more safely, sustainably and with fewer long-term risks using these recently approved drugs.

What NSI-189 dosage is recommended? Neuralstem used dosages of 40mg, 80mg, and 120mg in clinical trials, administered daily. The 80 and 120mg doses were given in multiple divided doses of 40mg each. Neuralstem is the pharmaceutical company that developed NSI-189 phosphate.

There are a couple of key differences between Vyvanse vs Adderall. These differences are important because they’ll inform your choice of ADHD medication.

The consensus is that psychostimulants like Adderall diminish testosterone.

Looking for other drugs in the same class as Gabapentin? We’ve compiled a large list of Gabapentin alternatives.

Modalert vs Provigil

November 7, 2016

Modalert, manufactured by Sun Pharmaceuticals in India, is the generic version of Provigil (modafinil).

Ritalin (methylphenidate) is a psychostimulant used for the treatment of ADHD and narcolepsy. Ritalin works by inhibiting the removal of dopamine, increasing the amount of dopamine available between brain connections (synapses).

A recent Nature paper[^1], published October 12, 2015, reports that transgenic Alzheimer’s mice have impaired slow wave sleep (SWS). Moreover, low-dose benzodiazepines and other GABA(A) agonists improve long-range slow wave coherence, thereby rescuing cognitive deficits in transgenic AD mice. These findings undermine the assumption that benzodiazepines are unequivocally bad for the brain. The deleterious effects of chronic, high-dose benzodiazepines on brain health remains unchallenged, however.