Trazodone did not influence sleep continuity and slow wave sleep, but did suppress REM sleep significantly. A significant increase of REM sleep latency was also found.
How does trazodone affect REM sleep?
Trazodone halved the frequency of arousals interrupting sleep, and it reduced the time spent in stage 1 (drowsiness). It increased the duration of slow-wave sleep (stages 3 + 4), with a negative rebound following withdrawal. It reduced the time spent in REM sleep, with a rebound above baseline levels after withdrawal.
Do you get REM sleep on trazodone?
Drowsiness is the most commonly reported side effect of trazodone. Because of its sedation, trazodone is currently more likely to be used as a hypnotic than as an antidepressant. PSG studies indicate that trazodone decreases sleep latency, may improve sleep continuity, increases SWS, but does not affect REM sleep.
What drugs interfere with REM sleep?
The three major classes of antidepressant drugs, monoamine oxidase inhibitors (MAOI), tricyclic antidepressants (TCA), and selective serotonin-reuptake inhibitors (SSRI), profoundly suppress REM sleep.
Does trazodone interfere with deep sleep?
The effects of trazodone on sleep were compared with those of placebo and the sedating tricyclic antidepressant trimipramine in a double-blind crossover study in six healthy young men. Only trazodone significantly increased deep sleep without otherwise altering the normal architecture of sleep.
Does trazodone affect memory?
Trazodone produced small but significant impairments of short-term memory, verbal learning, equilibrium, and arm muscle endurance across time points.
What was trazodone originally used for?
What is trazodone? Trazodone was developed in Italy in the 1960s as an antidepressant medication. Due to negative side effects associated with the drug early on—including dizziness, fainting, irregular heartbeat (and in rare cases, priapism in men)—the antidepressant wasn’t widely favored in the medical community.
Does trazodone work right away for sleep?
A handful of studies have shown that trazodone may improve sleep during the first two weeks of treatment. But the drug hasn’t been well-studied for longer than six weeks for people whose primary problem is insomnia.
What should you not take with trazodone?
Drugs you should not use with trazodone
Examples of these drugs include: Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, tranylcypromine, or selegiline. You shouldn’t take trazodone with MAOIs or within 14 days of taking them. Taking these drugs together raises your risk for serotonin syndrome.
Why is trazodone not helping me sleep?
Because of the chemical composition of trazodone, it has been found to have mild sedating effects, and it is less effective than other antidepressants for the treatment of depression. Therefore, trazodone has found greater utility as a sleep aid than it has as an antidepressant medication. You are not alone.
What happens when you suppress REM sleep?
Physically, REM sleep loss is associated with increased inflammatory responses, increased risk for obesity, and memory problems. Patients with sleep apnea, which may be associated with a complete loss of REM sleep, are at increased risk for cardiovascular disease, diabetes, obesity, and depression.
How do I increase my REM sleep?
Ways To Improve REM Sleep
Hydrating properly over the course of the day (not before bed, which can disrupt sleep for trips to the bathroom) Massage therapy or a steam room that day. Blue-light blocking glasses before bedtime. Reading in bed (the old-fashioned way) prior to falling asleep.