Newer atypical antipsychotics may carry less of a risk of metabolic side effects, but long-term data are lacking. Obtain baseline and periodic monitoring of BMI, waist circumference, HbA1c, fasting plasma glucose, and fasting lipids.
What are the side effects of atypical antipsychotics?
Common side effects of atypical antipsychotics include:
- Decreased sex drive.
- Weight gain.
- High cholesterol.
- Sun sensitivity.
What are the physical monitoring requirements for antipsychotics?
Before starting antipsychotic medication, the following baseline investigations should be undertaken and recorded:
- weight and height (both plotted on a growth chart)
- waist and hip circumference.
- pulse and blood pressure.
- fasting blood glucose, glycosylated haemoglobin (HbA1c), blood lipid profile and prolactin levels.
What do atypical antipsychotics act on?
Many atypical or second generation antipsychotics block serotonin (5-HT) receptors in the brain, particularly 5-HT2A receptors—the vital players in schizophrenia. In addition, atypical antipsychotics also act on adrenergic, cholinergic (muscarinic), and histamine receptors.
What do antipsychotic medications do?
Antipsychotic medications work by altering brain chemistry to help reduce psychotic symptoms like hallucinations, delusions and disordered thinking. They can also help prevent those symptoms from returning.
How do antipsychotics cause metabolic syndrome?
The mechanisms by which antipsychotic medications produce weight gain may include stimulating appetite, reducing physical activity and directly impairing metabolic regulation. The pathophysiology of weight gain is mediated through monoaminergic, cholinergic and histaminergic neurotransmission.
What is the most powerful antipsychotic medication?
Clozapine, which has the strongest antipsychotic effect, can cause neutropenia. A problem in the treatment of schizophrenia is poor patient compliance leading to the recurrence of psychotic symptoms.
What is the best atypical antipsychotic?
Olanzapine belongs to the thienobenzodiazepine class of psychotropic agents. It is indicated for the treatment of schizophrenia and is currently the only atypical antipsychotic approved for use in both acute and maintenance therapy of mixed or manic episodes associated with bipolar I disorder.
Which atypical antipsychotic drug has the lowest hypotensive effects?
Quetiapine and risperidone appear to have the lowest risk of hypertension.
How do you monitor antipsychotic compliance?
The most common method used to assess adherence was the report of the patient. Subjective and indirect methods including self-report, provider report, significant other report, and chart review were the only methods used to assess adherence in over 77% (124/161) of studies reviewed.
What labs are needed for antipsychotics?
COMPREHENSIVE METABOLIC PANEL (CMP), LIPIDS, FASTING GLUCOSE AND COMPLETE BLOOD COUNT (CBC) On initiation of any medication affecting this parameter and at least annually thereafter or more frequently as clinically indicated.
What are the side effects of antipsychotics?
What are the possible side effects of antipsychotics?
- Weight gain (the risk is higher with some atypical antipsychotic medicines)
- Dry mouth.