Which SSRI is least likely to cause withdrawal symptoms?

Fluoxetine, which has the longest half-life of the SSRIs (see Table 1), appears to produce the fewest withdrawal symptoms, while paroxetine, which has the shortest half-life, produces the most pronounced discontinuation effects.

Which SSRI is most likely to cause discontinuation syndrome?

Among the serotonin reuptake inhibitors, paroxetine is associated with the highest incidence of the syndrome and fluoxetine with the lowest. Because of venlafazine’s short half-life, the syndrome may occur more frequently following cessation and symptoms may be more severe.

Which antidepressant has the highest risk of withdrawal?

Key Messages. Antidepressants are associated with discontinuation phenomena. MAO inhibitors, tricyclic antidepressants, paroxetine, and venlafaxine carry high risk. With the exception of fluoxetine and agomelatine, antidepressants should be tapered over more than 4 weeks if possible.

What is the safest SSRI?

Citalopram and escitalopram have been considered the safest among the SSRIs with respect to potential for liver injury [41].

What is the safest antidepressant with the least side effects?

Antidepressants with the lowest rate of sexual side effects include:

  • Bupropion (Wellbutrin XL, Wellbutrin SR)
  • Mirtazapine (Remeron)
  • Vilazodone (Viibryd)
  • Vortioxetine (Trintellix)

How long after stopping antidepressants before I feel normal again?

In studies on adults with moderate or severe depression, 40–60% report improvements within 6–8 weeks. Those who wish to come off antidepressants because they feel better should ideally wait for at least 6–9 months after complete symptom remission before stopping their medication.

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What do brain zaps feel like?

You might also hear them referred to as “brain zaps,” “brain shocks,” “brain flips,” or “brain shivers.” They’re often described as feeling like brief electric jolts to the head that sometimes radiate to other body parts. Others describe it as feeling like the brain is briefly shivering.

Can SSRIs permanently change brain?

Selective serotonin reuptake inhibitors (SSRI) such as Prozac are regularly used to treat severe anxiety and depression. They work by immediately increasing the amount of serotonin in the brain and by causing long term changes in brain function.

What is serotonin withdrawal syndrome?

Frequency. 20-50% (with sudden stopping) Antidepressant discontinuation syndrome, also called antidepressant withdrawal syndrome, is a condition that can occur following the interruption, reduction, or discontinuation of antidepressant medication following its continuous use of at least a month.

Which SSRI is best for anxiety?

The antidepressants most widely prescribed for anxiety are SSRIs such as Prozac, Zoloft, Paxil, Lexapro, and Celexa.

Psychoactive drugs and substances