Which adverse reaction to antipsychotic medications carries the greatest risk of fatality?

A history of extrapyramidal side effects is the most significant risk factor, with a relative risk of about six10.

What is the most serious adverse response to antipsychotic medication?

First-generation antipsychotic drugs are more likely to cause adverse effects such as extrapyramidal symptoms and tardive dyskinesia. The most serious side effects of FGAs are neurological and are largely confined to the extrapyramidal motor system.

What is the main adverse effect to typical antipsychotic drugs?

All antipsychotic medications are associated with an increased likelihood of sedation, sexual dysfunction, postural hypotension, cardiac arrhythmia, and sudden cardiac death. Primary care physicians should understand the individual adverse effect profiles of these medications.

What is the most common neurological side effect of antipsychotic medication?

The specific neurologic side effects of the antipsychotic agents include acute dystonias, parkinsonism, motor restlessness, and late choretoathetosis.

Which is the most serious side effect of the newer antipsychotics?

Weight gain is a very common side effect of many antipsychotics, particularly some of the second generation (newer) drugs. This may be because antipsychotics increase your appetite, so you want to eat more than usual. They may also cause you to become less active, for example if they make you feel very tired.

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What is the weakest antipsychotic?

Of the atypical antipsychotics, risperidone is the weakest in terms of atypicality criteria. Although early clinical studies with risperidone indicated that the incidence of EPS is not greater than that seen with placebo, this may not be the case.

What is the strongest anti psychotic drug?

Clozapine, which has the strongest antipsychotic effect, can cause neutropenia. A problem in the treatment of schizophrenia is poor patient compliance leading to the recurrence of psychotic symptoms.

What is the most sedating antipsychotic?

The top ranked antipsychotics with the strongest association of sedation and somnolence were: zuclopenthixol (n = 224) ROR = 13.3 (95% CI, 11.6–15.3), tiapride (n = 76) ROR = 11.8 (95% CI, 9.3–15.0), and cyamemazine (n = 245) ROR = 10.7 (95% CI, 9.4–12.2).

What is the least sedating antipsychotic?

For example, the high-potency, low-dose atypical antipsychotic risperidone is less sedating than the lower-potency, high-dose atypical antipsychotics quetiapine and clozapine.

What antipsychotic has the least side effects?

Aripiprazole had less side- effects than olanzapine and risperidone (such as weight gain, sleepiness, heart problems, shaking and increased cholesterol levels).

Can you ever get off antipsychotics?

Some people may be able to stop taking antipsychotics without problems, but others can find it very difficult. If you have been taking them for some time, it can be more difficult to come off them. This is especially if you have been taking them for one year or longer.

Psychoactive drugs and substances