What were the first effective drugs used for the treatment of depression?

While iproniazid was marketed as an antitubercular compound under the trade name Marsilid® in 1958, it was used off-label to treat patients suffering from MDD. Thus, iproniazid became the first successful pharmacological treatment for depression and is classified as a MAO inhibitor.

What is the most effective drug for depression?

When the researchers checked which depression drugs were tolerated the best, these topped the list:

  • Celexa (citalopram)
  • Lexapro (escitalopram)
  • Prozac (fluoxetine)
  • Trintellix (vortioxetine)
  • Zoloft (sertraline)

When were SSRIs first used?

SSRI Antidepressants

Selective serotonin reuptake inhibitors were introduced to the market in 1987, with the introduction of Fluoxetine. The SSRIs were almost instantly popular because they were much safer. These drugs increase the amount of serotonin available in the brain.

What is the drug class typically used as a first-line treatment for depression?

Of the five major classes of antidepressants, selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are the most commonly prescribed, particularly in first-line treatment.

What are the top 5 antidepressants?

Antidepressants are drugs used to treat depression.

Examples of SSRIs are:

  • Prozac (fluoxetine)
  • Paxil (paroxetine)
  • Zoloft (sertraline)
  • Celexa (citalopram)
  • Luvox (fluvoxamine)
  • Lexapro (escitalopram)
  • Trintellix (vortioxetine)
  • Viibryd (vilazodone)
IT IS INTERESTING:  How fast will I lose weight on phentermine?

Which is the most powerful drug?

The Top 15 Most Dangerous Drugs

  • Clarithromycin. …
  • Clozapine. …
  • Cocaine. …
  • Colchicine. …
  • Cough Medicines. …
  • Digoxin. …
  • Heroin. …
  • Semi-Synthetic Opioids. Common semi-synthetic opioids include Percocet, Vicodin, and OxyContin.

Which SSRI is most effective?

Zoloft (sertraline): Zoloft is highly effective, although some people find it’s more likely than other SSRIs to cause diarrhea. Zoloft is the most commonly prescribed antidepressant; nearly 17% of those survey in the 2017 antidepressant use study reported that they had taken this medication. 1

What was the first antidepressant drug?

The 1950s saw the clinical introduction of the first two specifically antidepressant drugs: iproniazid, a monoamine-oxidase inhibitor that had been used in the treatment of tuberculosis, and imipramine, the first drug in the tricyclic antidepressant family.

Which SSRI has the worst side effects?

Overall, citalopram appears to be the best-tolerated SSRI, followed by fluoxetine, sertraline, paroxetine, and fluvoxamine. The latter 2 drugs are associated with the most side effects and the highest discontinuation rates because of side effects in clinical trials.

What are the anti depression drugs?

Selective serotonin reuptake inhibitors (SSRIs)

  • sertraline (Zoloft)
  • fluoxetine (Prozac, Sarafem)
  • citalopram (Celexa)
  • escitalopram (Lexapro)
  • paroxetine (Paxil, Pexeva, Brisdelle)
  • fluvoxamine (Luvox)

Are tricyclics better than SSRIs?

Conclusions: Overall efficacy between the two classes is comparable but SSRIs are not proven to be as effective as TCAs in in-patients and against amitriptyline. SSRIs have a modest advantage in terms of tolerability against most TCAs.

What is a mood stabilizer drug?

Mood stabilizers are medications used in the treatment of bipolar disorder, where a person’s mood changes from a depressed feeling to a high “manic” feeling or vice versa. These drugs can help reduce mood swings and prevent manic and depressive episodes.

IT IS INTERESTING:  Quick Answer: Which country escaped from Great Depression?
Psychoactive drugs and substances