Neuroleptic malignant syndrome can occur with atypical antipsychotic drugs such as olanzapine, particularly when risk factors are present. We should pay attention to this rare but life-threatening event associated with fatal complications.
Can olanzapine cause NMS?
Neuroleptic malignant syndrome can occur with atypical antipsychotics like olanzapine especially in the presence of risk factors. We should pay attention to this rare but potentially fatal complication. NMS remains a dangerous condition and has also been described in non-psychiatric settings.
What drugs cause neuroleptic malignant syndrome?
The primary trigger of NMS is dopamine receptor blockade and the standard causative agent is an antipsychotic. Potent typical neuroleptics such as haloperidol, fluphenazine, chlorpromazine, trifluoperazine, and prochlorperazine have been most frequently associated with NMS and thought to confer the greatest risk.
What antipsychotics cause neuroleptic malignant syndrome?
Atypical antipsychotic drugs that may cause NMS include the following:
Is neuroleptic malignant syndrome a side effect of antipsychotics?
Neuroleptic malignant syndrome is a rare but potentially life-threatening reaction to the use of almost any of a group of antipsychotic drugs or major tranquilizers (neuroleptics).
Can olanzapine cause excessive sweating?
Check with your doctor right away if you have difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, seizures, severe muscle stiffness, unusually pale skin, or tiredness.
What are the side effects of olanzapine?
Olanzapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness, feeling unsteady, or having trouble keeping your balance.
- unusual behavior.
- difficulty falling asleep or staying asleep.
- difficulty walking.
How long does it take to recover from neuroleptic malignant syndrome?
NMS usually gets better in 1 to 2 weeks. After recovery, most people can start taking antipsychotic medicine again. Your doctor might switch you to a different drug.
Which medication is associated with the highest risk of tardive dyskinesia?
Taking neuroleptics, especially over an extended period, is the biggest risk factor for developing tardive dyskinesia.
How is neuroleptic malignant diagnosed?
The diagnosis is confirmed by the presence of recent treatment with neuroleptics (within the past 1-4 weeks), hyperthermia (temperature above 38°C), and muscular rigidity, along with at least five of the following features: Change in mental status Tachycardia. Hypertension or hypotension.
Which atypical antipsychotic drug has the lowest hypotensive effects?
Quetiapine and risperidone appear to have the lowest risk of hypertension.
Are neuroleptics and antipsychotics the same thing?
Neuroleptics, also known as antipsychotic medications, are used to treat and manage symptoms of many psychiatric disorders. They fall into two classes: first-generation or “typical” antipsychotics, and second-generation or “atypical” antipsychotics.
Can antidepressants cause neuroleptic malignant syndrome?
An antidepressant-induced NMS is a very rare complication on the basis of pretreatment with neuroleptics causing chronic dopamine blockade and elevated plasma level of neuroleptics due to comedicated antidepressants.