Valproate is a mood stabilizer medication that works in the brain. It is approved for the treatment of mania associated with bipolar disorder (also known as manic depression), seizures (epilepsy), and migraine headaches. Bipolar disorder involves episodes of depression and/or mania.
Is valproate an antidepressant?
Valproate as an antidepressant in major depressive disorder.
Does valproic acid help with depression?
Valproic acid may be particularly helpful for patients who have symptoms of mania and depression occurring at the same time (a ‘mixed’ episode) or who have more than four mood episodes per year (this is called ‘rapid cycling’). This medication may also specifically target aggressive or impulsive behavioural problems.
Is sodium valproate good for anxiety?
The first and only double-blind, placebo-controlled randomized study that investigated the effectiveness of valproate in the treatment of anxiety disorders in 68 patients with generalized anxiety disorder reported that valproate significantly reduced anxiety symptoms compared to placebo [8.
How quickly does valproate work?
Sodium valproate may take several days to show an initial effect and in some cases may take from two to six weeks for maximum effect. Treatment is started with low doses and may be increased over a couple of weeks according to your child’s response.
What are the main side effects of sodium valproate?
Common side effects
- stomach pain, feeling or being sick (nausea or vomiting)
- dry or sore mouth, or swollen gums.
- shakes (tremors) in a part of your body, or unusual eye movements.
- feeling tired or sleepy.
- weight gain.
- thinning hair, or changes to the colour or texture of your hair.
Can sodium valproate make you depressed?
Conclusion. From our case series, it is suggested that the higher doses of valproate, such as those used in the treatment of acute mania, may cause a depressive switch following remission from the manic episode.
How does valproic acid make you feel?
Valproic acid may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you notice any of these side effects, tell your doctor right away.
What does valproic acid do for bipolar?
Valproic acid is an anticonvulsant (or anti-epileptic) medicine. We don’t fully understand how this medicine works for treating bipolar disorder. However valproic acid is thought to reduce or prevent manic episodes by increasing the amount of a chemical called gamma-aminobutyric acid (GABA) in the brain.
Is Depakote used for depression?
Depakote (divalproex sodium) and Abilify (aripiprazole) are used to treat manic episodes associated with bipolar disorder. Depakote is also used to treat epilepsy and migraine headaches. Abilify is also used to treat schizophrenia, depression, autistic disorder, and some irritable behavior disorders.
Is sodium valproate a mood stabilizer?
Because sodium valproate was initially discovered and used for the treatment of epilepsy, it is classified as an anticonvulsant rather than a mood stabilizer.
Is sodium valproate a sedative?
Sodium valproate is a commonly used antiepileptic drug (AED) for control of a broad range of seizures. Adverse drug reactions (ADR) due to sodium valproate range from sedation to nausea, vomiting, weight gain, idiosyncratic adverse effects like hepatotoxicity and life threatening conditions like pancreatitis.
What is the safest mood stabilizer?
The safest and most efficacious mood stabilizer combinations appear to be the mixtures of anticonvulsants and lithium, particularly valproate plus lithium.