Is quetiapine hard on the kidneys?

Background: Several adverse outcomes attributed to atypical antipsychotic drugs, specifically quetiapine, risperidone, and olanzapine, are known to cause acute kidney injury (AKI). Such outcomes include hypotension, acute urinary retention, and the neuroleptic malignant syndrome or rhabdomyolysis.

Is Seroquel hard on the kidneys?

The study, published Aug. 19 in Annals of Internal Medicine, found that acute kidney injury was one and a half times more likely in older adults taking Seroquel, Risperdal or Zyprexa compared to similar adults not taking these medications.

Can renal patients take quetiapine?

The single dose of quetiapine 25 mg generally was well tolerated in nonpsychotic subjects in good health or with either renal or hepatic impairments. Quetiapine also had no effect on the endogenous creatinine clearance of renally impaired or healthy control subjects.

What are the side effects of taking quetiapine?

Quetiapine may cause side effects. Tell your doctor if any of these symptoms or those listed in the SPECIAL PRECAUTIONS section are severe or do not go away:

  • dizziness, feeling unsteady, or having trouble keeping your balance.
  • pain in the joints, back, neck, or ears.
  • weakness.
  • dry mouth.
  • vomiting.
  • indigestion.
  • constipation.
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Can quetiapine cause health problems?

Quetiapine can cause changes in the way your body functions. You may have hyperglycemia (high blood sugar), increased cholesterol and triglycerides (fats in the blood), or weight gain. High blood sugar can occur in people with or without diabetes.

Is Seroquel safe to take for sleep?

It works by altering the levels of certain chemical messengers called neurotransmitters in your brain — in particular, serotonin and dopamine. Although it has a sedative effect, quetiapine isn’t recommended for insomnia.

Is 25mg of quetiapine a lot?

Off-label use was most evident for the 25 mg strength of quetiapine. The usual therapeutic dose range for the approved indications is 400–800 mg/day. The 25 mg dose has no uses that are evidence based other than for dose titration in older patients.

What does quetiapine do to the brain?

Quetiapine is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Quetiapine rebalances dopamine and serotonin to improve thinking, mood, and behavior.

How long should you take quetiapine?

Many people say that it takes four to six weeks for quetiapine to show its full effect. However, some people experience benefits sooner than this. You should stay in touch with your doctor to see how it goes over the first few weeks. They might do some tests to check your symptoms.

How long before bed should you take quetiapine?

Because it is an extended-release medicine, the dose should be taken once a day, 3-4 hours before bedtime. It is very important to follow your health care professional’s directions when you take SEROQUEL XR.

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Is quetiapine safe for long term use?

Quetiapine is a novel, atypical antipsychotic agent that has been shown to provide long-term efficacy without serious adverse effects in adults. This is the first study of the extended use of quetiapine in adolescents.

How safe is quetiapine?

Serious adverse events identified from case reports included fatal hepatotoxicity, restless legs syndrome, akathisia, and weight gain. Conclusions: There are potential safety concerns when using low-dose quetiapine for treatment of insomnia. These concerns should be evaluated in further prospective studies.

Psychoactive drugs and substances