Serotonin is transported by platelets and released upon activation. This induces constriction of injured blood vessels and enhances platelet aggregation to minimize blood loss.
How do SSRIs affect platelets?
SSRIs decrease an important platelet component called serotonin, which may cause bleeding in some patients. SSRIs include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox) and citalopram (Celexa).
Is serotonin in blood platelets?
Peripheral serotonin has long been proposed to be the ideal marker,18 because blood serotonin is contained in platelets. Platelets also share a similar serotonin uptake and release mechanism with serotonergic neurons.
How does serotonin affect blood clotting?
Serotonin appears to have a therapeutic effect on the postirradiation coagulation defect in that it decreases the prolonged heparin clotting time.
Which antidepressants do not affect platelets?
These findings suggest that escitalopram may be associated with decreased platelet count, and bupropion is less likely to exert an influence on platelet count. IT IS WELL known that depression and antidepressants affect platelets.
What is the most common cause of low platelet count?
Factors that can decrease platelet production include: Leukemia and other cancers. Some types of anemia. Viral infections, such as hepatitis C or HIV.
Does your brain produce serotonin?
Although serotonin is manufactured in the brain, where it performs its primary functions, some 90% of our serotonin supply is found in the digestive tract and in blood platelets.
Why do platelets need serotonin?
Serotonin is transported by platelets and released upon activation. This induces constriction of injured blood vessels and enhances platelet aggregation to minimize blood loss. Consequently, serotonin receptor antagonists have been tested for their anti-ischemic potency in atherothrombotic disease.
Can low platelets cause depression?
Fatigue (even in the absence of anemia), anxiety, and depression are common experiences for some people with ITP resulting in difficulties at work or school and also in social difficulties. These symptoms may be caused by the disease itself, by anxiety, or as side effects of medical treatment.
Do platelets release histamine?
Histamine is also metabolized by human platelets. The exposure of platelets to thrombin (10-60 mUml(-1)) produced a progressive aggregation, associated with histamine release. The same is observed in platelets isolated from atopic patients exposed to anti-IgE antibodies.