The drugs used to treat depression by affecting the brain’s use of the chemical serotonin — Prozac, Paxil, Zoloft — also tend to reduce the abnormalities in heart rhythm and blood clotting. For cardiac patients, these antidepressants may act primarily as blood thinners, a complicated form of baby aspirin.
Do antidepressants thin your blood?
Platelets need the brain chemical serotonin to function properly. The most popular antidepressants on the market block the absorption of serotonin. The result, the researchers speculate, is that the drugs effectively act like blood thinners, increasing the risk of abnormal bleeding and hemorrhagic stroke.
How does sertraline affect bleeding?
Among SSRIs, those with the higher degree of serotonin reuptake inhibition, fluoxetine, paroxetine, and sertraline are more frequently associated with abnormal bleeding (2). SSRI use is associated with doubled risk of upper GI bleeding; bleeding at other sites has been less commonly reported (1).
Do antidepressants constrict blood vessels?
Shah said the connection between heart health and antidepressants is poorly understood, adding that the medications may increase levels of chemical messengers like serotonin and norepineprine – which, in turn, might cause blood vessels to constrict or tighten, boosting blood pressure, a risk factor for atherosclerosis.
How does zoloft make you feel at first?
Your doctor may start you on a low dose and gradually increase the dose over time. It’s common to experience headaches, nausea, and fatigue during your first week on Zoloft. These side effects often get better over the first week or two.
Does Zoloft mess with your hormones?
Acute administration of SSRIs increases the secretion of several hormones, but chronic treatment with SSRIs does not alter basal blood levels of hormones. However, adaptive changes are induced by long-term treatment with SSRIs in serotonergic, noradrenergic and peptidergic neural function.
Why should you not take sertraline on a night?
Many people who experience nausea and other side effects from sertraline opt to take it at night in order to limit these side effects. Since sertraline can interfere with sleep in a small percentage of users, many people also opt to take sertraline in the morning.
What are the long term effects of taking sertraline?
To date, there are no known problems associated with long term use of sertraline. It is a safe and effective medication when used as directed.
Can sertraline cause sudden death?
Zoloft increases the blood level of pimozide (Orap) by 40%. High levels of pimozide can affect electrical conduction in the heart and lead to sudden death.
What are the worst side effects of Zoloft?
Tell your doctor if you have serious side effects of Zoloft including:
- very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
- agitation, hallucinations, fever, overactive reflexes, tremors;