Sustained use of the antipsychotic olanzapine in patients with remitted psychotic depression was associated with a thinning of the cortex, when compared with placebo, according to a study published online in JAMA Psychiatry.
What does olanzapine do to the brain?
Olanzapine is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Olanzapine rebalances dopamine and serotonin to improve thinking, mood, and behavior.
Do antipsychotics cause permanent brain damage?
Moncrieff’s second point is that the psychiatric establishment, underpinned by the pharmaceutical industry, has glossed over studies showing that antipsychotics cause extensive damage – the most startling being permanent brain atrophy (brain damage) or tardive dyskinesia.
Does olanzapine cause memory loss?
In contrast, olanzapine had significant sedative effects. Moreover, the subjects displayed a significant impairment on all measures of psychomotor function and verbal memory, which was not attributable to the drug’s sedative effects.
Is olanzapine safe for long-term use?
High doses or long-term use of olanzapine can cause a serious movement disorder that may not be reversible. The longer you use olanzapine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.
What happens when you stop taking olanzapine?
Stopping olanzapine suddenly can cause withdrawal effects and stopping it too early could cause your illness to come back. See your doctor if you want to stop taking olanzapine because it is better to come off it gradually. You might feel sleepy or dizzy in the first few days after taking olanzapine.
Can you ever get off antipsychotics?
Some people may be able to stop taking antipsychotics without problems, but others can find it very difficult. If you have been taking them for some time, it can be more difficult to come off them. This is especially if you have been taking them for one year or longer.
What is the safest antipsychotic drug?
Clozapine and olanzapine have the safest therapeutic effect, while the side effect of neutropenia must be controlled by 3 weekly blood controls. If schizophrenia has remitted and if patients show a good compliance, the adverse effects can be controlled.
Who shouldnt take olanzapine?
low levels of white blood cells. low levels of a type of white blood cell called neutrophils. suicidal thoughts. a type of movement disorder called parkinsonism.
Does olanzapine shrink the brain?
“We found that the mean reduction in cortical thickness caused by 36 weeks of exposure to olanzapine is equivalent to loss of approximately 1.2% of a person’s cortex,” researchers wrote. …
Does olanzapine improve memory?
Improvements in verbal learning and memory, sustained attention, and psychomotor tracking were independent of improvement in psychopathology. These data suggest that olanzapine improved some but not all cognitive deficits in schizophrenia, including verbal memory, a cognitive domain impaired by anticholinergic drugs.