If you’re on antidepressants, or are considering taking them, it’s worth examining some of the risks. That’s because selective serotonin reuptake inhibitors (SSRIs), one of the most widely prescribed classes of drugs to treat depression, have been found to carry a significantly increased risk of internal bleeding.
Can antidepressants cause bleeding?
Researchers say the risk of bleeding associated with antidepressants is due to the brain chemical serotonin, a chemical messenger that plays a role in depression and anxiety. Most antidepressants affect serotonin.
Do SSRIs cause gastrointestinal bleeding?
Being over the age of 80 or having a previous history of GI bleeding adds to the risk of upper GI bleeding with SSRIs. The risk may also be higher in patients who have just started taking SSRIs, and in those taking SSRIs with a high/intermediate affinity for the serotonin receptor.
What organs are affected by antidepressants?
It’s widely known that brain serotonin affects mood, and that most commonly used antidepressant treatment for depression blocks the absorption of serotonin by neurons. It is less widely known, though, that all the major organs of the body — the heart, kidneys, lungs, liver — use serotonin from the bloodstream.
Can Zoloft cause internal bleeding?
The large study shows that people taking selective serotonin reuptake inhibitors (SSRIs) — such as Prozac, Zoloft, and Paxil — were nearly four times as likely to be hospitalized with stomach or intestinal bleeding than people not taking one of these antidepressants.
How does serotonin affect bleeding?
Background Serotonin plays a role in platelet aggregation. Because antidepressants influence blood serotonin levels, their use may be associated with an increased risk of abnormal bleeding.
How does serotonin cause bleeding?
SSRIs inhibit the serotonin transporter, which is responsible for the uptake of serotonin into platelets. It could thus be predicted that SSRIs would deplete platelet serotonin, leading to a reduced ability to form clots and a subsequent increase in the risk of bleeding.
Which antidepressant does not increase risk of bleeding?
Antidepressants with low or no affinity for the serotonin transporter, such as bupropion or mirtazapine, may be appropriate alternatives for patients at risk of bleeding.
What are the signs of a GI bleed?
What are the symptoms of GI bleeding?
- black or tarry stool.
- bright red blood in vomit.
- cramps in the abdomen.
- dark or bright red blood mixed with stool.
- dizziness or faintness.
- feeling tired.
- shortness of breath.
Do antidepressants affect liver?
All antidepressants can induce hepatotoxicity, especially in elderly patients and those with polypharmacy. Liver damage is in most cases idiosyncratic and unpredictable, and it is generally unrelated to drug dosage.
How long do side effects of antidepressants last?
Many of these side effects will go away as your body gets used to the medication. It takes 2 weeks on average, but most go away within a few days, Coulter says. Some, like sexual issues and weight gain, may last longer.