A recent Nature paper[^1], published October 12, 2015, reports that transgenic Alzheimer’s mice have impaired slow wave sleep (SWS). Moreover, low-dose benzodiazepines and other GABA(A) agonists improve long-range slow wave coherence, thereby rescuing cognitive deficits in transgenic AD mice. These findings undermine the assumption that benzodiazepines are unequivocally bad for the brain. The deleterious effects of chronic, high-dose benzodiazepines on brain health remains unchallenged, however.

Tianeptine side effects are considered mild and tolerable in comparison to many other antidepressants. The incidence of very serious tianeptine side effects like liver injury and addiction are rare.

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December 15, 2016

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